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Molecular Profile | RAD51C T132P |
Therapy | Cisplatin + Paclitaxel |
Indication/Tumor Type | ovarian cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RAD51C T132P | ovarian cancer | sensitive | Cisplatin + Paclitaxel | Case Reports/Case Series | Actionable | In a clinical case study, treatment with Platinol (cisplatin) plus Taxol (paclitaxel) following surgery resulted in a response with a progression-free survival of at least 10 years in a patient with ovarian cancer harboring RAD51C T132P, and preclinical studies demonstrated cells expressing RAD51C T132P were sensitive to Platinol (cisplatin) in culture (PMID: 33832919). | 33832919 |
PubMed Id | Reference Title | Details |
---|---|---|
(33832919) | Long-term survival of an ovarian cancer patient harboring a RAD51C missense mutation. | Full reference... |