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| Molecular Profile | ERBB3 act mut |
| Therapy | Neratinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 act mut | Advanced Solid Tumor | sensitive | Neratinib | Preclinical | Actionable | In a preclinical study, transformed cells expressing ERBB3 (HER3) activating mutations demonstrated sensitivity to Nerlynx (neratinib), resulting in inhibition of Erbb3 (Her3) phosphorylation, downstream signaling, and cell growth (Cancer Res October 1, 2014 74; 3419). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 3419: Frequency and function of ERBB3 mutations in bladder cancer | Full reference... |