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Molecular Profile FLT3 exon 14 ins FLT3 F691L
Therapy PHI-101
Indication/Tumor Type hematologic cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 F691L hematologic cancer predicted - sensitive PHI-101 Preclinical - Biochemical Actionable In a preclinical study, PHI-101 demonstrated activity against FLT3 F691L in the context of a FLT3-ITD mutation in culture (Cancer Res 2020;80(16 Suppl):Abstract nr 4226). detail...
FLT3 exon 14 ins FLT3 F691L hematologic cancer predicted - sensitive PHI-101 Preclinical - Cell line xenograft Actionable In a preclinical study, PHI-101 decreased leukemia burden in a cell line xenograft model expressing FLT3 F691L in the context of a FLT3-ITD mutation (Blood (2020) 136 (Supplement 1): 802). detail...
PubMed Id Reference Title Details
PHI-101 Is a Potent Third-Generation FLT3 Inhibitor Developed to Overcome Resistance in Acute Myeloid Leukemia Full reference...
Abstract 4226: PHI-101, a next generation FLT3 inhibitor for acute myeloid leukemia Full reference...