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Molecular Profile | FLT3 exon 14 ins FLT3 A848P |
Therapy | Sorafenib + Sunitinib |
Indication/Tumor Type | chronic myelomonocytic leukemia |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 A848P | chronic myelomonocytic leukemia | predicted - resistant | Sorafenib + Sunitinib | Case Reports/Case Series | Actionable | In a clinical case study, FLT3 A848P was identified after progression on the alternating treatment of Nexvar (sorafenib) and Sutent (sunitinib) in a patient with chronic myelomoncytic leukemia harboring a FLT3-ITD mutation (PMID: 20520641). | 20520641 |
PubMed Id | Reference Title | Details |
---|---|---|
(20520641) | Identification of a secondary FLT3/A848P mutation in a patient with FLT3-ITD-positive blast phase CMML and response to sunitinib and sorafenib. | Full reference... |