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Molecular Profile BRAF V600E MAP2K1 G128D
Therapy Vemurafenib
Indication/Tumor Type colon adenocarcinoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E MAP2K1 G128D colon adenocarcinoma resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, a colon adenocarcinoma cell line harboring BRAF V600E and expressing MAP2K1 G128D was resistant to Zelboraf (vemurafenib) in culture (PMID: 36442478). 36442478
PubMed Id Reference Title Details
(36442478) High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer. Full reference...