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Molecular Profile | RET C634W |
Therapy | TY-1091 |
Indication/Tumor Type | thyroid cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | thyroid cancer | predicted - sensitive | TY-1091 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TY-1091 inhibited proliferation in a thyroid cancer cell line harboring RET C634W in culture and inhibited tumor growth in a cell line xenograft model (Cancer Res (2023) 83 (7_Supplement): 3419). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 3419: TY-1091, a highly selective and potent second-generation RET inhibitor, demonstrates superior antitumor activity in multiple RET-mutant models | Full reference... |