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| Molecular Profile | BTK L528W |
| Therapy | NX-5948 |
| Indication/Tumor Type | diffuse large B-cell lymphoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK L528W | diffuse large B-cell lymphoma | predicted - sensitive | NX-5948 | Preclinical - Cell culture | Actionable | In a preclinical study, NX-5948 inhibited Btk signaling and proliferation of a diffuse large B-cell lymphoma cell line expressing BTK L528W in culture (Cancer Res (2023) 83 (7_Supplement): 2850). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 2850: NX-5948 promotes selective, sub-nanomolar degradation of inhibitor-resistant BTK mutants | Full reference... |