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| Molecular Profile | ERBB3 positive |
| Therapy | Canertinib |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | melanoma | sensitive | Canertinib | Preclinical | Actionable | In a preclinical study, ERBB3 (HER3)-positive melanoma cells were sensitive to Canertinib, resulting in decreased metastasis in mouse models (PMID: 25000258). | 25000258 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25000258) | ERBB3 is required for metastasis formation of melanoma cells. | Full reference... |