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Molecular Profile | BRAF G464E |
Therapy | PHI-501 |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF G464E | melanoma | predicted - sensitive | PHI-501 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PHI-501 inhibited growth and migration and induced apoptosis in a melanoma cell line harboring BRAF G464E in culture and inhibited tumor growth in a cell line xenograft model (Cancer Res (2023) 83 (7_Supplement): 1627). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 1627: PHI-501, a novel and potent pan-RAF inhibitor in metastatic melanoma | Full reference... |