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Molecular Profile | PTEN loss |
Therapy | unspecified PD-1 antibody |
Indication/Tumor Type | lung squamous cell carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | lung squamous cell carcinoma | predicted - resistant | unspecified PD-1 antibody | Preclinical | Actionable | In a preclinical study, a syngeneic mouse model of squamous cell lung cancer with PTEN loss demonstrated resistance to treatment with a PD-1 antibody (PMID: 37311042). | 37311042 |
PubMed Id | Reference Title | Details |
---|---|---|
(37311042) | PTEN Loss Confers Resistance to Anti-PD-1 Therapy in Non-Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells. | Full reference... |