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| Molecular Profile | RET M918T |
| Therapy | Ponatinib |
| Indication/Tumor Type | lung small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET M918T | lung small cell carcinoma | sensitive | Ponatinib | Preclinical | Actionable | In a preclinical study, Iclusig (ponatinib) inhibited growth of small cell lung carcinoma lines expressing RET M918T (PMID: 25122427). | 25122427 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25122427) | RET mutation and expression in small-cell lung cancer. | Full reference... |