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Molecular Profile | ALK F1245C |
Therapy | Ceritinib + Ribociclib |
Indication/Tumor Type | neuroblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK F1245C | neuroblastoma | sensitive | Ceritinib + Ribociclib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Zykadia (ceritinib) and Kisqali (ribociclib) inhibited proliferation in a neuroblastoma cell line harboring ALK F1245C in culture, and resulted in enhanced tumor growth inhibition compared to either Zykadia (ceritinib) or Kisqali (ribociclib) alone (P=0.04 and P<0.0001, respectively) and induced complete and sustained tumor regression in a patient-derived xenograft (PDX) model (PMID: 27986745). | 27986745 |
PubMed Id | Reference Title | Details |
---|---|---|
(27986745) | Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma. | Full reference... |