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Molecular Profile | TP53 mutant |
Therapy | MI-63 |
Indication/Tumor Type | neuroblastoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 mutant | neuroblastoma | resistant | MI-63 | Preclinical | Actionable | In a preclinical study, neuroblastoma cell lines harboring TP53 mutant were resistant to MI-63 mediated growth inhibition (PMID: 21725357). | 21725357 |
PubMed Id | Reference Title | Details |
---|---|---|
(21725357) | MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. | Full reference... |