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Molecular Profile | NRAS Q61K |
Therapy | 4SC-205 + Selumetinib |
Indication/Tumor Type | neuroblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS Q61K | neuroblastoma | sensitive | 4SC-205 + Selumetinib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of 4SC-205 and Koselugo (selumetinib) inhibited viability to a greater degree than either therapy alone in a neuroblastoma cell line harboring NRAS Q61K (PMID: 34709738). | 34709738 |
PubMed Id | Reference Title | Details |
---|---|---|
(34709738) | The oral KIF11 inhibitor 4SC-205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma models. | Full reference... |