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Molecular Profile | RB1 del |
Therapy | JQ1 + unspecified PD-L1 antibody |
Indication/Tumor Type | prostate cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RB1 del | prostate cancer | sensitive | JQ1 + unspecified PD-L1 antibody | Preclinical | Actionable | In a preclinical study, the combination of JQ1 and an anti-PD-L1 therapy inhibited tumor growth in a syngeneic mouse model of RB1-deficient prostate cancer (PMID: 37014264). | 37014264 |
PubMed Id | Reference Title | Details |
---|---|---|
(37014264) | BET Inhibition Sensitizes Immunologically Cold Rb-Deficient Prostate Cancer to Immune Checkpoint Blockade. | Full reference... |