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Molecular Profile | EML4 - ALK ALK G1202R |
Therapy | Lorlatinib + PF-07284892 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK G1202R | lung non-small cell carcinoma | predicted - sensitive | Lorlatinib + PF-07284892 | Case Reports/Case Series | Actionable | In a clinical case study, the combination of PF-07284892 and Lorbrena (lorlatinib) resulted in a partial response with a 50% tumor reduction after 6 weeks in a patient with non-small cell lung cancer harboring EML4-ALK and ALK G1202R, and the patient remained on the combination for 4.5 months (PMID: 37269335; NCT04800822). | 37269335 |
PubMed Id | Reference Title | Details |
---|---|---|
(37269335) | SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. | Full reference... |