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Molecular Profile | NRAS G12S |
Therapy | IHMT-RAF-128 |
Indication/Tumor Type | acute lymphoblastic leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G12S | acute lymphoblastic leukemia | sensitive | IHMT-RAF-128 | Preclinical - Cell culture | Actionable | In a preclinical study, IHMT-RAF-128 inhibited proliferation in an acute lymphoblastic leukemia cell line harboring NRAS G12S in culture (PMID: 37164118). | 37164118 |
PubMed Id | Reference Title | Details |
---|---|---|
(37164118) | Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment. | Full reference... |