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Molecular Profile | BRAF V487_P492delinsA |
Therapy | IHMT-RAF-128 |
Indication/Tumor Type | pancreatic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V487_P492delinsA | pancreatic cancer | sensitive | IHMT-RAF-128 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, IHMT-RAF-128 inhibited proliferation in a pancreatic cancer cell line harboring BRAF V487_P492delinsA in culture and inhibited tumor growth in a cell line xenograft model (PMID: 37164118). | 37164118 |
PubMed Id | Reference Title | Details |
---|---|---|
(37164118) | Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment. | Full reference... |