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Molecular Profile | FGFR3 S249C PIK3CA E545K |
Therapy | Erdafitinib + Pictilisib |
Indication/Tumor Type | transitional cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 S249C PIK3CA E545K | transitional cell carcinoma | sensitive | Erdafitinib + Pictilisib | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, combination treatment with Balversa (erdafitinib) and Pictilisib (GDC-0941) resulted in synergistic inhibition of tumor growth in a patient-derived xenograft (PDX) model of urothelial cancer harboring FGFR3 S249C and PIK3CA E545K (PMID: 37377403). | 37377403 |
PubMed Id | Reference Title | Details |
---|---|---|
(37377403) | Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer. | Full reference... |