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Molecular Profile | ALK C1156Y |
Therapy | Alectinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK C1156Y | Advanced Solid Tumor | sensitive | Alectinib | Preclinical - Biochemical | Actionable | In a preclinical study, ALK C1156Y was sensitive to Alecensa (alectinib) in an in vitro enzyme assay (PMID: 21575866). | 21575866 |
PubMed Id | Reference Title | Details |
---|---|---|
(21575866) | CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. | Full reference... |