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Molecular Profile | KMT2A rearrange |
Therapy | Blinatumomab |
Indication/Tumor Type | childhood B-cell acute lymphoblastic leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | childhood B-cell acute lymphoblastic leukemia | predicted - sensitive | Blinatumomab | Phase II | Actionable | In a Phase II trial, Blincyto (blinatumomab) treatment followed by a chemotherapy regimen with Cytoxan (cyclophosphamide), Cytosar-U (cytarabine), Mercaptopurine, MARMA, and OCTADAD demonstrated safety and resulted in minimal residual disease-negative or low in 93% (28/30) of infant patients with KMT2A-rearranged, B-precursor, acute lymphoblastic leukemia after infusion with Blincyto (blinatumomab), and a 2-year disease-free survival of 81.6% and an overall survival of 93.3% (PMID: 37099340). | 37099340 |
PubMed Id | Reference Title | Details |
---|---|---|
(37099340) | Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia. | Full reference... |