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Molecular Profile FGFR3 S249C FGFR3 V553L
Therapy Pemigatinib
Indication/Tumor Type transitional cell carcinoma
Response Type not predictive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S249C FGFR3 V553L transitional cell carcinoma not predictive Pemigatinib Case Reports/Case Series Actionable In a clinical case study, FGFR3 V553L was identified in the post-progression biopsy of a patient with upper tract urothelial carcinoma harboring FGFR3 S249C who previously responded to Pemazyre (pemigatinib) treatment (PMID: 37377403). 37377403
PubMed Id Reference Title Details
(37377403) Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer. Full reference...