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Molecular Profile | FGFR3 S249C FGFR3 V553L |
Therapy | Pemigatinib |
Indication/Tumor Type | transitional cell carcinoma |
Response Type | not predictive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 S249C FGFR3 V553L | transitional cell carcinoma | not predictive | Pemigatinib | Case Reports/Case Series | Actionable | In a clinical case study, FGFR3 V553L was identified in the post-progression biopsy of a patient with upper tract urothelial carcinoma harboring FGFR3 S249C who previously responded to Pemazyre (pemigatinib) treatment (PMID: 37377403). | 37377403 |
PubMed Id | Reference Title | Details |
---|---|---|
(37377403) | Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer. | Full reference... |