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Molecular Profile FGFR3 S249C TSC1 Q830*
Therapy Erdafitinib
Indication/Tumor Type bladder urothelial carcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 S249C TSC1 Q830* bladder urothelial carcinoma predicted - resistant Erdafitinib Case Reports/Case Series Actionable In a clinical case study, TSC1 Q830* was identified in the post-progression tissue biopsy and circulating tumor DNA (ctDNA) together with TSC1 Q830* in the post-progression ctDNA of a patient with bladder urothelial cancer harboring FGFR3 S249C who previously responded to Balversa (erdafitinib) treatment (PMID: 37377403). 37377403
PubMed Id Reference Title Details
(37377403) Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer. Full reference...