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Molecular Profile BRAF V600E CDKN2A R80*
Therapy Dabrafenib + Palbociclib + Trametinib
Indication/Tumor Type rhabdomyosarcoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E CDKN2A R80* rhabdomyosarcoma predicted - sensitive Dabrafenib + Palbociclib + Trametinib Case Reports/Case Series Actionable In a clinical case study, the combination of Tafinlar (dabrafenib), Ibrance (palbociclib), and Mekinist (trametinib) resulted in a progression-free survival of 9 months in a patient with rhabdomyosarcoma harboring BRAF V600E and CDKN2A R80* (PMID: 33472910). 33472910
PubMed Id Reference Title Details
(33472910) Concomitant MEK and Cyclin Gene Alterations: Implications for Response to Targeted Therapeutics. Full reference...