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Molecular Profile | BRAF V600E CDKN2A R80* |
Therapy | Dabrafenib + Palbociclib + Trametinib |
Indication/Tumor Type | rhabdomyosarcoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E CDKN2A R80* | rhabdomyosarcoma | predicted - sensitive | Dabrafenib + Palbociclib + Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, the combination of Tafinlar (dabrafenib), Ibrance (palbociclib), and Mekinist (trametinib) resulted in a progression-free survival of 9 months in a patient with rhabdomyosarcoma harboring BRAF V600E and CDKN2A R80* (PMID: 33472910). | 33472910 |
PubMed Id | Reference Title | Details |
---|---|---|
(33472910) | Concomitant MEK and Cyclin Gene Alterations: Implications for Response to Targeted Therapeutics. | Full reference... |