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Molecular Profile | PIK3CA E545K |
Therapy | Trametinib |
Indication/Tumor Type | diffuse midline glioma, H3 K27M-mutant |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | diffuse midline glioma, H3 K27M-mutant | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, Mekinist (trametinib) inhibited viability of mouse glioma cells expressing H3.1 K28M (reported as H3.1 K27M), ACVR1 G328V, and PIK3CA E545K in culture (PMID: 37011011). | 37011011 |
PubMed Id | Reference Title | Details |
---|---|---|
(37011011) | A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities. | Full reference... |