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| Molecular Profile | MSH6 negative |
| Therapy | Carboplatin + Dostarlimab-gxly + Paclitaxel |
| Indication/Tumor Type | endometrial cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH6 negative | endometrial cancer | sensitive | Carboplatin + Dostarlimab-gxly + Paclitaxel | Phase III | Actionable | In a Phase III trial (RUBY), Jemperli (dostarlimab-gxly) plus carboplatin and paclitaxel followed by Jemperli (dostarlimab-gxly) improved 24-month progression-free survival (61.4% vs 15.7%, HR 0.28, p<0.001) compared to placebo in patients with advanced or recurrent mismatch repair-deficient (dMMR, as indicated by a loss of MLH1, PMS2, MSH2, or MSH6 expression in an FDA-approved IHC test) or microsatellite instability-high (MSI-H) endometrial cancer (PMID: 36972026; NCT03981796). | 36972026 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36972026) | Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer. | Full reference... |