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Molecular Profile | PIK3CA E545G |
Therapy | MK2206 |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545G | urinary bladder cancer | sensitive | MK2206 | Preclinical - Cell culture | Actionable | In a preclinical study, MK2206 increased apoptosis and inhibited viability in a bladder cancer cell line harboring PIK3CA E545G in culture (PMID: 25349966). | 25349966 |
PubMed Id | Reference Title | Details |
---|---|---|
(25349966) | Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy. | Full reference... |