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Molecular Profile | RET D898_E901del |
Therapy | Vandetanib |
Indication/Tumor Type | medullary thyroid carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET D898_E901del | medullary thyroid carcinoma | predicted - resistant | Vandetanib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with metastatic medullary thyroid carcinoma harboring RET D898_E901del demonstrated primary resistance to Caprelsa (vandetanib) treatment (PMID: 37535881). | 37535881 |
PubMed Id | Reference Title | Details |
---|---|---|
(37535881) | D898_E901 RET Deletion Is Oncogenic, Responds to Selpercatinib, and Treatment Resistance Can Arise Via RET-Independent Mechanisms. | Full reference... |