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Molecular Profile | BRAF G469A MDM2 amp TP53 wild-type |
Therapy | Milademetan + Trametinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF G469A MDM2 amp TP53 wild-type | lung adenocarcinoma | sensitive | Milademetan + Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of Mekinist (trametinib) and Milademetan synergistically inhibited proliferation in a lung adenocarcinoma cell line harboring BRAF G469A with wild-type TP53 and MDM2 amplification in culture (PMID: 37182602). | 37182602 |
PubMed Id | Reference Title | Details |
---|---|---|
(37182602) | Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification. | Full reference... |