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| Molecular Profile | PIK3CA E545K |
| Therapy | Alpelisib + Toripalimab-tpzi |
| Indication/Tumor Type | cervical cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | cervical cancer | sensitive | Alpelisib + Toripalimab-tpzi | Preclinical - Pdx | Actionable | In a preclinical study, the combination of Piqray (alpelisib) and Loqtorz (toripalimab-tpzi) inhibited proliferation in cell line xenograft models of cervical cancer harboring PIK3CA E545K and in a patient-derived xenograft (PDX) model (PMID: 37469254). | 37469254 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37469254) | Targeting PI3Kα increases the efficacy of anti-PD-1 antibody in cervical cancer. | Full reference... |