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Molecular Profile | PIK3CA H1047R |
Therapy | Gedatolisib |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA H1047R | breast cancer | sensitive | Gedatolisib | Preclinical | Actionable | In a preclinical study, Gedatolisib (PKI-587) inhibited growth of human breast cancer cells harboring PIK3CA H1047R in culture (PMID: 21325073, PMID: 17314276). | 17314276 21325073 |
PubMed Id | Reference Title | Details |
---|---|---|
(21325073) | Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor. | Full reference... |
(17314276) | Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. | Full reference... |