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| Molecular Profile | APC inact mut |
| Therapy | CCT031374 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colorectal cancer | sensitive | CCT031374 | Preclinical | Actionable | In a preclinical study, CCT031374 inhibited Wnt pathway activation and growth of colorectal cancer cell lines harboring APC inactivating mutations in culture (PMID: 20610623). | 20610623 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20610623) | A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. | Full reference... |