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| Molecular Profile | APC inact mut |
| Therapy | NC043 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colorectal cancer | sensitive | NC043 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NC043 inhibited Wnt pathway activation and growth of colorectal cancer cell lines harboring APC truncation mutations in culture and in cell line xenograft models (PMID: 21321609). | 21321609 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21321609) | A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. | Full reference... |