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| Molecular Profile | CTNNB1 mutant |
| Therapy | BC21 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CTNNB1 mutant | colorectal cancer | sensitive | BC21 | Preclinical | Actionable | In a preclinical study, BC21 inhibited growth and viability of a colorectal cancer cell line with a CTNNB1 mutation and increased beta-catenin expression in culture (PMID: 22224445). | 22224445 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22224445) | Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. | Full reference... |