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Molecular Profile | FLT3 Q575del |
Therapy | Crenolanib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 Q575del | hematologic cancer | sensitive | Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, Crenolanib (CP-868596) decreased proliferation in transformed cells expressing FLT3 Q575del in culture (PMID: 33914060). | 33914060 |
PubMed Id | Reference Title | Details |
---|---|---|
(33914060) | Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis. | Full reference... |