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Molecular Profile | APC inact mut |
Therapy | Pyrvinium |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colorectal cancer | sensitive | Pyrvinium | Preclinical | Actionable | In a preclinical study, Pyrvinium inhibited Wnt signaling and decreased viability of colon cancer cells harboring APC mutations in culture (PMID: 20890287). | 20890287 |
PubMed Id | Reference Title | Details |
---|---|---|
(20890287) | Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. | Full reference... |