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Molecular Profile | PBRM1 mutant |
Therapy | unspecified PD-L1 antibody |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PBRM1 mutant | lung non-small cell carcinoma | predicted - resistant | unspecified PD-L1 antibody | Clinical Study - Cohort | Actionable | In a clinical study, treatment with either an anti-PD-1 or anti-PD-L1 therapy resulted in a significantly shorter overall survival (p=0.0057) and progression-free survival (p=0.03) in patients with non-small cell lung cancer harboring a PBRM1 mutation compared to patients with wild-type PBRM1 (PMID: 36456601). | 36456601 |
PubMed Id | Reference Title | Details |
---|---|---|
(36456601) | Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB. | Full reference... |