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Molecular Profile | APC inact mut |
Therapy | G007-LK |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colon cancer | sensitive | G007-LK | Preclinical - Cell line xenograft | Actionable | In a preclinical study, G007-LK inhibited growth of APC-mutant colorectal cancer cell lines in culture and in xenograft models (PMID: 23539443). | 23539443 |
PubMed Id | Reference Title | Details |
---|---|---|
(23539443) | A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. | Full reference... |