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Molecular Profile | FLT3 D586_D593delinsGG |
Therapy | Sorafenib |
Indication/Tumor Type | hematologic cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D586_D593delinsGG | hematologic cancer | predicted - sensitive | Sorafenib | Preclinical - Biochemical | Actionable | In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 D586_D593delinsGG in culture (PMID: 37246158). | 37246158 |
PubMed Id | Reference Title | Details |
---|---|---|
(37246158) | Mutation spectrum of FLT3 and significance of non-canonical FLT3 mutations in haematological malignancy. | Full reference... |