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| Molecular Profile | FLT3 F590_D593delinsGP |
| Therapy | Sorafenib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 F590_D593delinsGP | hematologic cancer | predicted - sensitive | Sorafenib | Preclinical - Biochemical | Actionable | In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 F590_D593delinsGP in culture (PMID: 37246158). | 37246158 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37246158) | Mutation spectrum of FLT3 and significance of non-canonical FLT3 mutations in haematological malignancy. | Full reference... |