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Molecular Profile | FLT3 E598_Y599del |
Therapy | Midostaurin |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 E598_Y599del | hematologic cancer | sensitive | Midostaurin | Preclinical - Cell culture | Actionable | In a preclinical study, Rydapt (midostaurin) inhibited Flt3 and Stat5 phosphorylation and viability in cells expressing FLT3 E598_Y599del in culture (PMID: 26012842). | 26012842 |
PubMed Id | Reference Title | Details |
---|---|---|
(26012842) | Rare FLT3 deletion mutants may provide additional treatment options to patients with AML: an approach to individualized medicine. | Full reference... |