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Molecular Profile FLT3 E598_Y599del
Therapy Quizartinib
Indication/Tumor Type hematologic cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 E598_Y599del hematologic cancer sensitive Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) inhibited Flt3 and Stat5 phosphorylation and viability in cells expressing FLT3 E598_Y599del in culture (PMID: 26012842). 26012842
PubMed Id Reference Title Details
(26012842) Rare FLT3 deletion mutants may provide additional treatment options to patients with AML: an approach to individualized medicine. Full reference...