Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | FLT3 D835K FLT3 D835L |
Therapy | KW-2449 |
Indication/Tumor Type | hematologic cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835K FLT3 D835L | hematologic cancer | no benefit | KW-2449 | Preclinical - Cell culture | Actionable | In a preclinical study, KW-2449 did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). | 28077790 |
PubMed Id | Reference Title | Details |
---|---|---|
(28077790) | FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors. | Full reference... |