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Molecular Profile | FLT3 I836S |
Therapy | Crenolanib |
Indication/Tumor Type | hematologic cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 I836S | hematologic cancer | no benefit | Crenolanib | Preclinical - Cell culture | Actionable | In a preclinical study, Crenolanib (CP-868596) did not inhibit viability of transformed cells expressing FLT3 I836S in culture (PMID: 28077790). | 28077790 |
PubMed Id | Reference Title | Details |
---|---|---|
(28077790) | FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors. | Full reference... |