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| Molecular Profile | FLT3 I836T |
| Therapy | Lestaurtinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 I836T | hematologic cancer | sensitive | Lestaurtinib | Preclinical - Cell culture | Actionable | In a preclinical study, Lestaurtinib (CEP-701) inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 I836T in culture (PMID: 28077790). | 28077790 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28077790) | FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors. | Full reference... |