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Molecular Profile | RET C634W |
Therapy | Vepafestinib |
Indication/Tumor Type | medullary thyroid carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | medullary thyroid carcinoma | sensitive | Vepafestinib | Preclinical - Cell culture | Actionable | In a preclinical study, Vepafestinib (TAS0953/HM06) inhibited proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture (PMID: 37743366). | 37743366 |
PubMed Id | Reference Title | Details |
---|---|---|
(37743366) | Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations. | Full reference... |