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Molecular Profile RET C634W
Therapy Vepafestinib
Indication/Tumor Type medullary thyroid carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W medullary thyroid carcinoma sensitive Vepafestinib Preclinical - Cell culture Actionable In a preclinical study, Vepafestinib (TAS0953/HM06) inhibited proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture (PMID: 37743366). 37743366
PubMed Id Reference Title Details
(37743366) Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations. Full reference...