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Molecular Profile | ARID1A mutant |
Therapy | UNC1999 |
Indication/Tumor Type | ovarian cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A mutant | ovarian cancer | sensitive | UNC1999 | Preclinical - Cell culture | Actionable | In a preclinical study, UNC1999 inhibited growth of ovarian cancer cell lines harboring ARID1A mutations in culture (PMID: 25686104). | 25686104 |
PubMed Id | Reference Title | Details |
---|---|---|
(25686104) | Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. | Full reference... |