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| Molecular Profile | PIK3CA M1043V |
| Therapy | Alpelisib |
| Indication/Tumor Type | histiocytosis |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA M1043V | histiocytosis | predicted - sensitive | Alpelisib | Case Reports/Case Series | Actionable | In a clinical case study, Piqray (alpelisib) treatment resulted in symptom improvement and a complete metabolic response lasting at least 9 months in a patient with Langerhans cell histiocytosis harboring PIK3CA M1043V (PMID: 37874915). | 37874915 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37874915) | Mutant PIK3CA is a targetable driver alteration in histiocytic neoplasms. | Full reference... |