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Molecular Profile | ARID1A wild-type |
Therapy | GSK126 |
Indication/Tumor Type | ovarian cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A wild-type | ovarian cancer | no benefit | GSK126 | Preclinical - Cell culture | Actionable | In a preclinical study, GSK126 had no significant effect on the growth of ovarian cancer cells with wild-type ARID1A in culture (PMID: 25686104). | 25686104 |
PubMed Id | Reference Title | Details |
---|---|---|
(25686104) | Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. | Full reference... |