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Molecular Profile | PIK3CA H1047R |
Therapy | Alpelisib |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA H1047R | colorectal cancer | resistant | Alpelisib | Preclinical - Cell culture | Actionable | In a preclinical study, a colorectal cancer cell line harboring PIK3CA H1047R was resistant to Piqray (alpelisib) in culture (PMID: 37493631). | 37493631 |
PubMed Id | Reference Title | Details |
---|---|---|
(37493631) | CBF-Beta Mitigates PI3K-Alpha-Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer. | Full reference... |